Maple Sirup

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چکیده

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[Maple syrup urine disease].

Branched chain a-ketoacid dehydrogenase (BCKDH) deficiency results in maple syrup urine disease (MSUD). We examined the molecular basis of familial cases ofMSUD by analyzing the activity, subunit structure, mRNA sequence, and genome structure of the affected enzyme. The BCKDH activity in the proband with MSUD was 6% ofthe normal control level. Immunoblot analysis revealed that the ElB subunit o...

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ژورنال

عنوان ژورنال: Applied Microbiology

سال: 1959

ISSN: 0003-6919

DOI: 10.1128/aem.7.3.152-155.1959